In the ongoing struggle to manage weight, finding hope might feel like an uphill battle. I understand. I’ve been there, supporting patients searching for a solution after years of trying.

Today, I’ll discuss new weight loss medications: Wegovy and Mounjaro. While they may sound like sci-fi planets, they offer real hope. They can be a fresh start for those feeling discouraged by past attempts.

After exploring these treatments and seeing their effects firsthand, I want you to know that you’re not alone in this journey. Let’s compare Wegovy and Mounjaro to find the right support for your weight loss goals.

Table of Contents
Which is more effective: Wegovy or Mounjaro
Can I switch from Wegovy to Mounjaro
What are Mounjaro and Wegovy
How do you take Mounjaro for weight loss
How do you take Wegovy for weight loss
How Mounjaro works in the body
How Wegovy works in the body
Summary of clinical trials conducted on Mounjaro
Summary of clinical trials conducted on Wegovy

Which is more effective: Wegovy or Mounjaro?

Both Wegovy and Mounjaro show effectiveness in weight loss. Clinical studies indicate that individuals can shed up to 22.5% of their weight with Mounjaro and up to 15% with Wegovy. Since the active ingredients vary slightly, you might discover that one treatment suits you better or has fewer side effects.

Can I switch from Wegovy to Mounjaro?

Sure, you can switch from Wegovy to Mounjaro, but it’s best to wait at least 5 weeks in between. This allows enough time for any remaining Wegovy medication to clear from your system before starting Mounjaro safely. Regardless of your Wegovy dose, you’ll begin with the lowest Mounjaro dose and follow the dosing plan. If you’re considering switching, it’s a good idea to talk to your Crest Pharmacy Clinician for a safe transition.

What are the active ingredients in Mounjaro and Wegovy?

The active ingredients in Mounjaro and Wegovy differ significantly. Mounjaro contains tirzepatide, which activates both GLP-1 and GIP receptors. This helps control blood sugar and aids weight loss for type 2 diabetes or weight management. Mounjaro uses tirzepatide for these metabolic benefits instead of semaglutide.

Wegovy has semaglutide as its only active ingredient. This targets GLP-1 receptors to reduce appetite and promote weight loss. Semaglutide in Wegovy acts like natural GLP-1 hormones that control appetite, aiding weight loss in obesity or related conditions.

To help track your progress using one of these medications you can use our example weight tracker below:

How do you take Mounjaro for weight loss?

Use Mounjaro once a week, whenever suits you best! We get it, plans change. If you need to switch the day you take it, just make sure to wait at least 3 days (72 hours) between doses.

If you miss a dose, take it within 4 days (96 hours) of the missed one. After 4 days, skip it and stick to your regular schedule. Remember not to double up within 3 days.

Consider setting a phone reminder for your Mounjaro day. If you change the day, update your reminder too! Mounjaro comes in a single-dose pen that requires no mixing.

There is no need to see or handle the needle!

How do you take Wegovy for weight loss?

Line up the pen straight against your injection site so you can clearly see the pen’s window. Ready to start the injection? Just push the pen firmly against your skin. Keep pressing the pen against your skin for the whole injection, taking about 10 seconds. Feel free to take your Wegovy® at any time of day that suits you best. Need a reminder? Try integrating your weekly dose into your routine. What’s something you do on the same day every week?

How Mounjaro works in the body

As a dual GLP-1/GIP receptor agonist, Mounjaro plays a role in weight and blood sugar management through a few key pathways:

• Boosts insulin production for better glucose utilisation
• Reduces glucagon secretion to lower blood sugar levels
• Slows stomach emptying and nutrient absorption in the intestines
• Engages brain regions tied to appetite to enhance feelings of fullness

Together, these effects work towards better glycemic control, appetite management, and significant weight loss.

How Wegovy works in the body

Since Wegovy only contains semaglutide, it mainly impacts physiology through one avenue: GLP-1 receptor activation. This leads to the following benefits:

• Slowed stomach emptying to keep you feeling satisfied after meals
• Increased signals of fullness to your brain, helping to control your appetite and food intake
• Maintaining stable blood sugar levels even with fewer calories consumed

While glucagon and insulin activity are not affected without GIP, the boosted GLP-1 stimulation enables Wegovy to provide effective weight management with few side effects.

Summary of clinical trials conducted on Mounjaro

Mounjaro has been through six Phase 3 trials with over 3000 patients who have type 2 diabetes. These trials lasted between 24-72 weeks. Here are some highlights:

• HbA1c reductions from 0.6% to 1.9%
• Up to 84% of patients achieved HbA1c under 7%
• Average weight loss of 13-22 lbs
• Blood pressure decreases ranged from 2-7 mmHg

In addition to better glucose control, more than a quarter of patients on the highest doses lost at least 20% of their body weight.

Summary of clinical trials conducted on Wegovy

Wegovy has been studied in 4 pivotal trials involving nearly 4000 overweight or obese adults without diabetes. These trials lasted up to 68 weeks. Here are some key findings:

• People achieved an average weight loss of 12-15% in all phase 3 trials.
• The percentage of individuals losing ≥15% body weight varied from 34-63%, depending on the dose and duration.
• There were significant reductions in cardiovascular and metabolic disease markers.
• Wegovy did not negatively impact bone mineral density or renal function.

Wegovy’s weight reductions are comparable to traditional bariatric surgeries, highlighting its effectiveness as an anti-obesity medication.

In conclusion, while both Mounjaro and Wegovy offer promising results in the fight against obesity and its related complications, Mounjaro appears to edge out as the superior option for many. Its broader applicability to individuals with type 2 diabetes, significant reductions in HbA1c levels, and substantial weight loss over a wide patient demographic underscore its effectiveness.

Not to mention the added benefit of achieving blood pressure reduction and the potential for substantial weight loss without the severe side effects often associated with obesity and diabetes medications mark Mounjaro as a groundbreaking treatment option.

Its comprehensive approach in managing both weight and blood sugar levels positions Mounjaro not just as a treatment for obesity or diabetes in isolation, but as a holistic healthcare solution fostering overall health and well-being.

If you’re ready to take the first step towards a healthier future and explore these groundbreaking treatment options, we invite you to complete our consultation form. A Crest Pharmacy Clinician will be in touch to discuss your results and guide you through the next steps tailored to your health goals.

Don’t wait any longer to take control of your health. Fill out the form today, and let’s begin this journey together.

Sources

https://www.novomedlink.com/obesity/products/treatments/wegovy/efficacy-safety/clinical-trial-1-results.html
https://investor.lilly.com/news-releases/news-release-details/tirzepatide-demonstrated-significant-and-superior-weight-loss